Proteasome Endopeptidase Complex

A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Also Known As:

Proteasome; Multicatalytic Endopeptidase Complex; 20S Proteasome; Ingensin; Macropain; Macroxyproteinase; Multicatalytic Proteinase; Prosome; Complex, Multicatalytic Endopeptidase; Complex, Proteasome Endopeptidase; Endopeptidase Complex, Multicatalytic; Endopeptidase Complex, Proteasome; Proteasome, 20S; Proteinase, Multicatalytic

Macromolecular Substances: 97
- Multiprotein Complexes: 128
  - Multienzyme Complexes: 8
    - Proteasome Endopeptidase Complex: 7287
Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Proteasome Endopeptidase Complex: 7287
  - Multienzyme Complexes: 8
    - Proteasome Endopeptidase Complex: 7287

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Disease

Drug/Important Bio-Agent (IBA)